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Exercise activates redox-sensitive transcription factors and restores renal D(1) receptor function in old rats
We have previously reported that age-associated oxidative stress via protein kinase C (PKC) increases D(1) receptor (D1R) phosphorylation and causes D1R-G protein uncoupling in renal proximal tubules (RPTs) of old Fischer 344 rats. This results in reduced ability of D1R agonist SKF-38393 to inhibit...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Physiological Society
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781333/ https://ncbi.nlm.nih.gov/pubmed/19759268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00397.2009 |
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