Designer Monotransregulators Provide a Basis for a Transcriptional Therapy for de novo Endocrine-Resistant Breast Cancer

The main circulating estrogen hormone 17β-estradiol (E2) contributes to the initiation and progression of breast cancer. Estrogen receptors (ERs), as transcription factors, mediate the effects of E2. Ablation of the circulating E2 and/or prevention of ER functions constitute approaches for ER-positi...

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Autores principales: Nott, Stephanie L., Huang, Yanfang, Kalkanoglu, Aja, Harper, Kathryn, Chen, Ming, Paoni, Scott F., Fenton, Bruce M., Muyan, Mesut
Formato: Artigo
Lenguaje:Inglês
Publicado: ScholarOne 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781301/
https://ncbi.nlm.nih.gov/pubmed/19946606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2009.00107
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