EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet–Fed Mice

OBJECTIVE: In obesity, an increased macrophage infiltration in adipose tissue occurs, contributing to low-grade inflammation and insulin resistance. Epidermal growth factor receptor (EGFR) mediates both chemotaxis and proliferation in monocytes and macrophages. However, the role of EGFR inhibitors i...

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Detalhes bibliográficos
Main Authors: Prada, Patricia O., Ropelle, Eduardo R., Mourão, Rosa H., de Souza, Claudio T., Pauli, Jose R., Cintra, Dennys E., Schenka, André, Rocco, Silvana A., Rittner, Roberto, Franchini, Kleber G., Vassallo, José, Velloso, Lício A., Carvalheira, José B., Saad, Mario J.A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780887/
https://ncbi.nlm.nih.gov/pubmed/19696185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0506
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