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A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota
A T cell receptor transgenic mouse line reactive to a microbiota flagellin, CBir1, was used to define mechanisms of host microbiota homeostasis. Intestinal IgA, but not serum IgA, was found to block mucosal flagellin uptake and systemic T cell activation in mice. Depletion of CD4(+)CD25(+) Tregs dec...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2780781/ https://ncbi.nlm.nih.gov/pubmed/19889972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812681106 |
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