Carbon Monoxide Blocks Lipopolysaccharide-Induced Gene Expression by Interfering with Proximal TLR4 to NF-κB Signal Transduction in Human Monocytes

Carbon monoxide (CO) is an endogenous messenger that suppresses inflammation, modulates apoptosis and promotes vascular remodeling. Here, microarrays were employed to globally characterize the CO (250 ppm) suppression of early (1 h) LPS-induced inflammation in human monocytic THP-1 cells. CO suppres...

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Bibliographic Details
Main Authors: Chhikara, Maneesha, Wang, Shuibang, Kern, Steven J., Ferreyra, Gabriela A., Barb, Jennifer J., Munson, Peter J., Danner, Robert L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780718/
https://ncbi.nlm.nih.gov/pubmed/19956541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008139
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