Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by Gemcitabine in an androgen-reduced environment

We examined the efficacy of combination treatments utilizing cytotoxic drugs plus inhibitors to members of the ErbB - ERK signal pathway in human prostate cancer (PCa) LNCaP C-81 cells. Under an androgen-reduced condition, 50 nM gemcitabine caused about 40% growth suppression on C-81 cells. Simultan...

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Hlavní autoři: Zhang, Li, Davis, Jeffrey S., Zelivianski, Stanislav, Lin, Fen-Fen, Schutte, Rachel, Davis, Thomas L., Hauke, Ralph, Batra, Surinder K., Lin, Ming-Fong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780578/
https://ncbi.nlm.nih.gov/pubmed/19467571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2009.04.041
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