ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression

We show that combinatorial mouse alleles for the secreted metalloproteases Adamts5, Adamts20 (bt), and Adamts9 result in fully penetrant soft-tissue syndactyly. Interdigital webs in Adamts5−/−; bt/bt mice had reduced apoptosis and decreased cleavage of the proteoglycan versican; however, the BMP-FGF...

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Bibliografiske detaljer
Main Authors: McCulloch, Daniel R., Nelson, Courtney M., Dixon, Laura J., Silver, Debra L., Wylie, James D., Lindner, Volkhard, Sasaki, Takako, Cooley, Marion A., Argraves, W. Scott, Apte, Suneel S.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780442/
https://ncbi.nlm.nih.gov/pubmed/19922873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.09.008
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