In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation

AIMS: To study the impact of risperidone (RISP) on clozapine (CLZ) biotransformation in vitro in microsomal fractions containing varying expression of CYP oxidases and in vivo in patients. METHODS: Human liver microsomes (n= 11) were assessed for expression of CYPs 1A2, 2D6 and 3A4, because these en...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chetty, Manoranjenni, d'Esposito, Fabrizio, Zhang, Wei V, Glen, John, Dore, Glenys, Stankovic, Zvijezdana, Edwards, Robert J, Ramzan, Iqbal, Murray, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780282/
https://ncbi.nlm.nih.gov/pubmed/19843060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03476.x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados