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In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation

AIMS: To study the impact of risperidone (RISP) on clozapine (CLZ) biotransformation in vitro in microsomal fractions containing varying expression of CYP oxidases and in vivo in patients. METHODS: Human liver microsomes (n= 11) were assessed for expression of CYPs 1A2, 2D6 and 3A4, because these en...

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Autori principali: Chetty, Manoranjenni, d'Esposito, Fabrizio, Zhang, Wei V, Glen, John, Dore, Glenys, Stankovic, Zvijezdana, Edwards, Robert J, Ramzan, Iqbal, Murray, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780282/
https://ncbi.nlm.nih.gov/pubmed/19843060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03476.x
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