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Disruption of the Proton Relay Network in the Class 2 Dihydroorotate Dehydrogenase from Escherichia coli
Dihydroorotate dehydrogenases (DHODs) are FMN-containing enzymes that catalyze the conversion of dihydroorotate (DHO) to orotate in the de novo synthesis of pyrimidines. During the reaction, a proton is transferred from C5 of DHO to an active site base and the hydrogen at C6 of DHO is transferred to...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2780000/ https://ncbi.nlm.nih.gov/pubmed/19694481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901024m |
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