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Gene conversion causing human inherited disease: evidence for involvement of non-B-DNA-forming sequences and recombination-promoting motifs in DNA breakage and repair

A variety of DNA sequence motifs including inverted repeats, minisatellites, and the χ recombination hotspot, have been reported in association with gene conversion in human genes causing inherited disease. However, no methodical statistically-based analysis has been performed to formalize these obs...

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Main Authors: Chuzhanova, Nadia, Chen, Jian-Min, Bacolla, Albino, Patrinos, George P., Férec, Claude, Wells, Robert D., Cooper, David N.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779867/
https://ncbi.nlm.nih.gov/pubmed/19431182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21020
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