Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
The amyloid precursor protein (APP) plays a crucial role in the pathogenesis of Alzheimer’s disease. During intracellular transport APP undergoes a series of proteolytic cleavages that lead to the release either of an amyloidogenic fragment called β-amyloid (Aβ) or of a nonamyloidogenic secreted for...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1998
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600988/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.6460 |
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