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Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

The amyloid precursor protein (APP) plays a crucial role in the pathogenesis of Alzheimer’s disease. During intracellular transport APP undergoes a series of proteolytic cleavages that lead to the release either of an amyloidogenic fragment called β-amyloid (Aβ) or of a nonamyloidogenic secreted for...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Simons, Mikael, Keller, Patrick, De Strooper, Bart, Beyreuther, Konrad, Dotti, Carlos G., Simons, Kai
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27798/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600988/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.6460
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