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Three-Kinase Inhibitor Combination Recreates Multi-Pathway Effects of a Geldanamycin Analog on Hepatocellular Carcinoma Cell Death

Multi-target compounds that act on a diverse set of regulatory pathways are emerging as a therapeutic approach for a variety of cancers. Toward a more specified use of this approach, we hypothesize that the desired efficacy can be recreated in terms of a particular combination of relatively more spe...

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Detalhes bibliográficos
Main Authors: Pritchard, Justin R., Cosgrove, Benjamin D., Hemann, Michael T., Griffith, Linda G., Wands, Jack R., Lauffenburger, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779718/
https://ncbi.nlm.nih.gov/pubmed/19671754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1203
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