Enhanced anti-tumor activity induced by adoptive T cell transfer and the adjunctive use of the HDAC Inhibitor LAQ824

Tumors grow in the presence of antigen-specific T cells, suggesting the existence of intrinsic cancer cell escape mechanisms. We hypothesized that a histone deacetylase (HDAC) inhibitor could sensitize tumor cells to immunotherapy because this class of agents has been reported to increase tumor anti...

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Detalhes bibliográficos
Principais autores: Vo, Dan D., Prins, Robert M., Begley, Jonathan L., Donahue, Timothy R., Morris, Lilah F., Bruhn, Kevin W., de la Rocha, Pilar, Yang, Meng-Yin, Mok, Stephen, Garban, Hermes J., Craft, Noah, Economou, James S., Marincola, Francesco M., Wang, Ena, Ribas, Antoni
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779578/
https://ncbi.nlm.nih.gov/pubmed/19861533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1456
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