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The oncogene Cdc37 is a molecular chaperone: Targeting The Kinome’s Favorite Aunt

Cdc37 is a molecular chaperone that physically stabilizes the catalytic domains found in protein kinases and is therefore a wide-spectrum regulator of protein phosphorylation. It is also an overexpressed oncogene that mediates carcinogenesis by stabilizing the compromised structures of mutant and/or...

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Bibliografiska uppgifter
Huvudupphovsmän: Gray, Phillip J., Prince, Thomas, Cheng, Jinrong, Stevenson, Mary Ann, Calderwood, Stuart K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779120/
https://ncbi.nlm.nih.gov/pubmed/18511936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2420
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