Expression of an IKKγ Splice Variant Determines IRF3 and Canonical NF-κB Pathway Utilization in ssRNA Virus Infection

Single stranded RNA (ssRNA) virus infection activates the retinoic acid inducible gene I (RIG-I)- mitochondrial antiviral signaling (MAVS) complex, a complex that coordinates the host innate immune response via the NF-κB and IRF3 pathways. Recent work has shown that the IκB kinase (IKK)γ scaffolding...

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Detalhes bibliográficos
Main Authors: Liu, Ping, Lu, Muping, Tian, Bing, Li, Kui, Garofalo, Roberto P., Prusak, Deborah, Wood, Thomas G., Brasier, Allan R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778955/
https://ncbi.nlm.nih.gov/pubmed/19956647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008079
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