An Alternative Splice Product of IκB Kinase (IKKγ), IKKγ-Δ, Differentially Mediates Cytokine and Human T-Cell Leukemia Virus Type 1 Tax-Induced NF-κB Activation

NF-κB is an inducible transcription factor mediating innate immune responses whose activity is controlled by the multiprotein IκB kinase (IKK) “signalsome”. The core IKK consists of two catalytic serine kinases, IKKα and IKKβ, and a noncatalytic subunit, IKKγ. IKKγ is required for IKK activity by me...

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Detalhes bibliográficos
Main Authors: Hai, Tao, Yeung, Man-Lung, Wood, Thomas G., Wei, Yuanfen, Yamaoka, Shoji, Gatalica, Zoran, Jeang, Kuan-Teh, Brasier, Allan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472011/
https://ncbi.nlm.nih.gov/pubmed/16611882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.9.4227-4241.2006
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