Combinatorial anti-leukemic disruption of oxidative homeostasis and mitochondrial stability by the redox reactive thalidomide CPS49 and flavopiridol

CPS49 is a member of a recently identified class of redox-reactive thalidomide analogs that show selective killing of leukemic cells by increasing intra-cellular reactive oxygen species (ROS) and targeting multiple transcriptional pathways. Flavopiridol is a semisynthetic flavonoid that inhibits cyc...

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Autores principales: Ge, Yun, Byun, Jung S., De Luca, Paola, Gueron, Geraldine, Yabe, Idalia, Sadiq-Ali, Sara G., Figg, William D., Quintero, Jesse, Haggerty, Cynthia M., Li, Quentin Q., De Siervi, Adriana, Gardner, Kevin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778846/
https://ncbi.nlm.nih.gov/pubmed/18556456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.040808
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