A Noisy Paracrine Signal Determines the Cellular NF-κB Response to Lipopolysaccharide

Nearly identical cells can exhibit substantially different responses to the same stimulus. We monitored the nuclear localization dynamics of nuclear factor κB (NF-κB) in single cells stimulated with tumor necrosis factor-α (TNF-α) and lipopolysaccharide (LPS). Cells stimulated with TNF-α have quanti...

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Bibliografiske detaljer
Main Authors: Lee, Timothy K., Denny, Elissa M., Sanghvi, Jayodita C., Gaston, Jahlionais E., Maynard, Nathaniel D., Hughey, Jacob J., Covert, Markus W.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778577/
https://ncbi.nlm.nih.gov/pubmed/19843957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000599
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