Why build whole-cell models?

Por Carrera, Javier, Covert, Markus W.
Publicado no Trends Cell Biol (2015)

High-throughput, single-cell NF-κB dynamics

Por Lee, Timothy K., Covert, Markus W.
Publicado em 2010

WholeCellViz: data visualization for whole-cell models

Por Lee, Ruby, Karr, Jonathan R, Covert, Markus W
Publicado em 2013

Incorporation of Flexible Objectives and Time-Linked Simulation with Flux Balance Analysis

Por Birch, Elsa W., Udell, Madeleine, Covert, Markus W.
Publicado em 2013

Reconciling Gene Expression Data With Known Genome-Scale Regulatory Network Structures

Por Herrgård, Markus J., Covert, Markus W., Palsson, Bernhard ø.
Publicado em 2003

Computational Modeling of Mammalian Signaling Networks

Por Hughey, Jacob J, Lee, Timothy K, Covert, Markus W
Publicado em 2010

Determining Host Metabolic Limitations on Viral Replication via Integrated Modeling and Experimental Perturbation

Por Birch, Elsa W., Ruggero, Nicholas A., Covert, Markus W.
Publicado em 2012

WholeCellSimDB: a hybrid relational/HDF database for whole-cell model predictions

Por Karr, Jonathan R., Phillips, Nolan C., Covert, Markus W.
Publicado em 2014

The Future of Whole-Cell Modeling

Por Macklin, Derek N., Ruggero, Nicholas A., Covert, Markus W.
Publicado em 2014

Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting

Por Maynard, Nathaniel D, Macklin, Derek N, Kirkegaard, Karla, Covert, Markus W
Publicado em 2012

Nonlytic viral spread enhanced by autophagy components

Por Bird, Sara Whitney, Maynard, Nathaniel D., Covert, Markus W., Kirkegaard, Karla
Publicado no Proc Natl Acad Sci U S A (2014)

Single-cell variation leads to population invariance in NF-κB signaling dynamics

Por Hughey, Jacob J., Gutschow, Miriam V., Bajar, Bryce T., Covert, Markus W.
Publicado no Mol Biol Cell (2015)

The Virus as Metabolic Engineer

Por Maynard, Nathaniel D., Gutschow, Miriam V., Birch, Elsa W., Covert, Markus W.
Publicado em 2010

High-sensitivity measurements of multiple kinase activities in live single cells

Por Regot, Sergi, Hughey, Jacob J., Bajar, Bryce T., Carrasco, Silvia, Covert, Markus W.
Publicado em 2014

A dynamic network of transcription in LPS-treated human subjects

Por Seok, Junhee, Xiao, Wenzhong, Moldawer, Lyle L, Davis, Ronald W, Covert, Markus W
Publicado em 2009

Towards a whole-cell modeling approach for synthetic biology

Por Purcell, Oliver, Jain, Bonny, Karr, Jonathan R., Covert, Markus W., Lu, Timothy K.
Publicado em 2013

WholeCellKB: model organism databases for comprehensive whole-cell models

Por Karr, Jonathan R., Sanghvi, Jayodita C., Macklin, Derek N., Arora, Abhishek, Covert, Markus W.
Publicado em 2013

Genome-Scale Metabolic Model of Helicobacter pylori 26695

Por Schilling, Christophe H., Covert, Markus W., Famili, Iman, Church, George M., Edwards, Jeremy S., Palsson, Bernhard O.
Publicado em 2002

Single-cell NF-κB dynamics reveal digital activation and analog information processing in cells

Por Tay, Savaş, Hughey, Jacob J., Lee, Timothy K., Lipniacki, Tomasz, Quake, Stephen R., Covert, Markus W.
Publicado em 2010

A Forward-Genetic Screen and Dynamic Analysis of Lambda Phage Host-Dependencies Reveals an Extensive Interaction Network and a New Anti-Viral Strategy

Por Maynard, Nathaniel D., Birch, Elsa W., Sanghvi, Jayodita C., Chen, Lu, Gutschow, Miriam V., Covert, Markus W.
Publicado em 2010