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A Novel 5'-Iodonucleoside Allows Efficient Nonenzymatic Ligation of Single-stranded and Duplex DNAs

A new iodothymidine phosphoramidite enables the placement of a 5'-iodide into oligonucleotides; the iodide is stable to ammonia deprotection and allows nonenzymatic ligations of DNA.

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Bibliographic Details
Main Authors: Xu, Yanzheng, Kool, Eric T.
Format: Artigo
Language:Inglês
Published: 1997
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778307/
https://ncbi.nlm.nih.gov/pubmed/19924262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0040-4039(97)01266-5
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