A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain

Dynorphin peptides and the kappa opioid receptor play important roles in the rewarding properties of cocaine, heroin and alcohol. We tested polymorphisms of the prodynorphin gene (PDYN) for association with cocaine dependence and cocaine/alcohol codependence. We genotyped six SNPs, located in the pr...

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Detalhes bibliográficos
Main Authors: Yuferov, Vadim, Ji, Fei, Nielsen, David A., Levran, Orna, Ho, Ann, Morgello, Susan, Shi, Ruijin, Ott, Jurg, Kreek, Mary Jeanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778041/
https://ncbi.nlm.nih.gov/pubmed/18923396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2008.187
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