Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1.) In phase 2, we genotyped the 15,008 highest-ranked SNPs in 2,057 Scottish cases and 2,111 controls. We the...

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Main Authors: Tenesa, Albert, Farrington, Susan M, Prendergast, James GD, Porteous, Mary E, Walker, Marion, Haq, Naila, Barnetson, Rebecca A, Theodoratou, Evropi, Cetnarskyj, Roseanne, Cartwright, Nicola, Semple, Colin, Clark, Andrew J, Reid, Fiona JL, Smith, Lorna A, Kavoussanakis, Kostas, Koessler, Thibaud, Pharoah, Paul DP, Buch, Stephan, Schafmayer, Clemens, Tepel, Jürgen, Schreiber, Stefan, Völzke, Henry, Schmidt, Carsten O, Hampe, Jochen, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Wilkening, Stefan, Canzian, Federico, Capella, Gabriel, Moreno, Victor, Deary, Ian J, Starr, John M, Tomlinson, Ian PM, Kemp, Zoe, Howarth, Kimberley, Carvajal-Carmona, Luis, Webb, Emily, Broderick, Peter, Vijayakrishnan, Jayaram, Houlston, Richard S, Rennert, Gad, Ballinger, Dennis, Rozek, Laura, Gruber, Stephen B, Matsuda, Koichi, Kidokoro, Tomohide, Nakamura, Yusuke, Zanke, Brent W, Greenwood, Celia MT, Rangrej, Jagadish, Kustra, Rafal, Montpetit, Alexandre, Hudson, Thomas J, Gallinger, Steven, Campbell, Harry, Dunlop, Malcolm G
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778004/
https://ncbi.nlm.nih.gov/pubmed/18372901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.133
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