Proteasome Inactivation Promotes p38 Mitogen-activated Protein Kinase-dependent Phosphatidylinositol 3-kinase Activation and Increases Interleukin-8 Production in Retinal Pigment Epithelial Cells

Oxidative stress and inflammation are implicated in the pathogenesis of many age-related diseases. We have demonstrated previously that oxidative inactivation of the proteasome is a molecular link between oxidative stress and overexpression of interleukin (IL)-8. Here, we elucidated a novel signalin...

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Main Authors: Fernandes, Alexandre F., Bian, Qingning, Jiang, Jian-Kang, Thomas, Craig J., Taylor, Allen, Pereira, Paulo, Shang, Fu
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777929/
https://ncbi.nlm.nih.gov/pubmed/19570915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-10-1068
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