Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9

BACKGROUND: IL-2 has classically been considered a cytokine that regulates T cell proliferation and differentiation, signaling through its heterotrimeric receptor (IL-2R) consisting of α (CD25), β (CD122), γ chains (CD132). Expression of IL-2R has also been detected in mucosal epithelial cells. Solu...

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Detalhes bibliográficos
Main Authors: De Paiva, Cintia S, Yoon, Kyung-Chul, Pangelinan, Solherny B, Pham, Sapa, Puthenparambil, Larry M, Chuang, Eliseu Y, Farley, William J, Stern, Michael E, Li, De-Quan, Pflugfelder, Stephen C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777897/
https://ncbi.nlm.nih.gov/pubmed/19878594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-6-31
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