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Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes

The oncogene EVI1 has been implicated in the etiology of AML and MDS. Although AML cells are characterized by accelerated proliferation and differentiation arrest, MDS cells hyperproliferate when immature but fail to differentiate later and die instead. In agreement with its roles in AML and in imma...

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Main Authors: Konrad, Torsten A., Karger, Anna, Hackl, Hubert, Schwarzinger, Ilse, Herbacek, Irene, Wieser, Rotraud
Format: Artigo
Jezik:Inglês
Izdano: The Society for Leukocyte Biology 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777892/
https://ncbi.nlm.nih.gov/pubmed/19605700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0109042
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