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Optical imaging of matrix metalloproteinase-7 activity in vivo using a proteolytic nanobeacon

Matrix metalloproteinases (MMPs) are extracellular proteolytic enzymes involved in tumor progression. We present the in vivo detection and quantitation of MMP7 activity using a specific near-infrared polymer-based proteolytic beacon, PB-M7NIR. PB-M7NIR is a pegylated polyamidoamine PAMAM-Generation...

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Main Authors: Scherer, Randy L., VanSaun, Michael N., McIntyre, Oliver, Matrisian, Lynn M.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777890/
https://ncbi.nlm.nih.gov/pubmed/19123982
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