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Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis

We used recombinant adeno-associated virus (rAAV)-mediated gene delivery to overexpress a mutant of rat leptin yielding a protein that acts as a neutral leptin receptor antagonist. The long-term consequences of this overexpression on body weight homeostasis and physical activity, as assessed by volu...

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Hlavní autoři: Matheny, Michael, Zhang, Yi, Shapiro, Alexandra, Tümer, Nihal, Scarpace, Philip J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777784/
https://ncbi.nlm.nih.gov/pubmed/19726711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.90449.2008
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