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Cutting Edge: Ikaros Null Thymocytes Mature into the CD4 Lineage with Reduced TCR Signal: A Study Using CD3ζ Immunoreceptor Tyrosine-Based Activation Motif Transgenic Mice
Positive selection is a critical T cell developmental checkpoint that is driven by TCR signals. Enhanced positive selection toward the CD4 lineage occurs in the absence of Ikaros. One explanation for this phenotype is that Ikaros establishes the TCR signaling threshold that must be overcome for posi...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777666/ https://ncbi.nlm.nih.gov/pubmed/19299690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802869 |
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