A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling

Poxviruses employ many strategies to evade and neutralize the host immune response. In this study, we have identified two vaccinia virus ORFs, termed A46R and A52R, that share amino acid sequence similarity with the Toll/IL-1 receptor (TIR) domain, a motif that defines the IL-1/Toll-like receptor (T...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Bowie, Andrew, Kiss-Toth, Endre, Symons, Julian A., Smith, Geoffrey L., Dower, Steven K., O'Neill, Luke A. J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27775/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10920188/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160027697
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