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A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling

Poxviruses employ many strategies to evade and neutralize the host immune response. In this study, we have identified two vaccinia virus ORFs, termed A46R and A52R, that share amino acid sequence similarity with the Toll/IL-1 receptor (TIR) domain, a motif that defines the IL-1/Toll-like receptor (T...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Bowie, Andrew, Kiss-Toth, Endre, Symons, Julian A., Smith, Geoffrey L., Dower, Steven K., O'Neill, Luke A. J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27775/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10920188/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160027697
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