Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis

Objective. IL-23 is a pro-inflammatory cytokine proposed to be central to the development of autoimmune disease. We investigated whether IL-23, together with the downstream mediator IL-17A, was present and functional in RA in humans. Methods. RA synovial cells were cultured in the presence or absenc...

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Detalhes bibliográficos
Main Authors: Hillyer, Philippa, Larché, Maggie J., Bowman, Edward P., McClanahan, Terrill K., de Waal Malefyt, Rene, Schewitz, Lauren P., Giddins, Grey, Feldmann, Marc, Kastelein, Robert A., Brennan, Fionula M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Clinical
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777488/
https://ncbi.nlm.nih.gov/pubmed/19815670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kep293
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