A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is the only potentially curative treatment available for patients with B-cell chronic lymphocytic leukemia (B-CLL). Here, we show that post-alloHSCT antibody repertoires can be mined for the discovery of fully human monoclonal antibodies...

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Detalhes bibliográficos
Main Authors: Baskar, Sivasubramanian, Suschak, Jessica M., Samija, Ivan, Srinivasan, Ramaprasad, Childs, Richard W., Pavletic, Steven Z., Bishop, Michael R., Rader, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777128/
https://ncbi.nlm.nih.gov/pubmed/19667400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-222786
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