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Membrane Insertion of the Pleckstrin Homology Domain Variable Loop 1 Is Critical for Dynamin-catalyzed Vesicle Scission

The GTPase dynamin catalyzes the scission of deeply invaginated clathrin-coated pits at the plasma membrane, but the mechanisms governing dynamin-mediated membrane fission remain poorly understood. Through mutagenesis, we have altered the hydrophobic nature of the membrane-inserting variable loop 1...

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Bibliografiske detaljer
Main Authors: Ramachandran, Rajesh, Pucadyil, Thomas J., Liu, Ya-Wen, Acharya, Sharmistha, Leonard, Marilyn, Lukiyanchuk, Vasyl, Schmid, Sandra L.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777094/
https://ncbi.nlm.nih.gov/pubmed/19776347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-08-0683
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