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Immune complex relay by subcapsular sinus macrophages and non-cognate B cells drives antibody affinity maturation

Subcapsular sinus (SCS) macrophages capture antigens from lymph and present them intact for B cell encounter and follicular delivery. However, the properties of SCS macrophages are poorly defined. Here we show SCS macrophage development depended on lymphotoxin-α1β2 and the cells had low lysosomal en...

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Autors principals: Phan, Tri Giang, Green, Jesse A., Gray, Elizabeth E., Xu, Ying, Cyster, Jason G.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776777/
https://ncbi.nlm.nih.gov/pubmed/19503106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1745
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