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Immune complex relay by subcapsular sinus macrophages and non-cognate B cells drives antibody affinity maturation
Subcapsular sinus (SCS) macrophages capture antigens from lymph and present them intact for B cell encounter and follicular delivery. However, the properties of SCS macrophages are poorly defined. Here we show SCS macrophage development depended on lymphotoxin-α1β2 and the cells had low lysosomal en...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776777/ https://ncbi.nlm.nih.gov/pubmed/19503106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1745 |
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