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Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R
The aging program mediated by IGF1-R is responsible for a naturally occurring TrkA-to-p75(NTR) switch that leads to activation of the second messenger ceramide and increased production of the Alzheimer’s disease amyloid β-peptide. Biochemical and genetic approaches that target IGF1-R signaling, p75(...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776679/ https://ncbi.nlm.nih.gov/pubmed/18378044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2008.02.015 |
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