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Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R

The aging program mediated by IGF1-R is responsible for a naturally occurring TrkA-to-p75(NTR) switch that leads to activation of the second messenger ceramide and increased production of the Alzheimer’s disease amyloid β-peptide. Biochemical and genetic approaches that target IGF1-R signaling, p75(...

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Detalhes bibliográficos
Main Authors: Li, Hui, Costantini, Claudio, Scrable, Heidi, Weindruch, Richard, Puglielli, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776679/
https://ncbi.nlm.nih.gov/pubmed/18378044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2008.02.015
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