Discovery, Characterization and Comparison of Inhibitors of Bacillus anthracis and Staphylococcus aureus Replicative DNA Helicases

Antibacterial compounds with new mechanisms of action are needed for effective therapy against drug-resistant pathogens in the clinic and in biodefense. Screens for inhibitors of the essential replicative helicases of Bacillus anthracis and Staphylococcus aureus yielded 18 confirmed hits (IC(50) ≤ 2...

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Autori principali: Aiello, Daniel, Barnes, Marjorie H., Biswas, Esther E., Biswas, Subhasis B., Gu, Shen, Williams, John D., Bowlin, Terry L., Moir, Donald T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776654/
https://ncbi.nlm.nih.gov/pubmed/19477652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.014
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