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Quantification of rare allelic variants from pooled genomic DNA
Rare germline variants are difficult to identify using traditional sequencing due to relatively high cost and low throughput. Using second-generation sequencing, we report a targeted, cost-effective method to quantify rare SNPs from pooled genomic DNA. We pooled DNA from 1,111 individuals and target...
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| Main Authors: | , , , , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2009
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776647/ https://ncbi.nlm.nih.gov/pubmed/19252504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1307 |
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