Quantification of rare allelic variants from pooled genomic DNA

Rare germline variants are difficult to identify using traditional sequencing due to relatively high cost and low throughput. Using second-generation sequencing, we report a targeted, cost-effective method to quantify rare SNPs from pooled genomic DNA. We pooled DNA from 1,111 individuals and target...

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Detalhes bibliográficos
Main Authors: Druley, Todd E, Vallania, Francesco LM, Wegner, Daniel J, Varley, Katherine E, Knowles, Olivia L, Bonds, Jacqueline A, Robison, Sarah W, Doniger, Scott W, Hamvas, Aaron, Cole, F. Sessions, Fay, Justin C, Mitra, Robi D
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776647/
https://ncbi.nlm.nih.gov/pubmed/19252504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1307
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