Quantification of rare allelic variants from pooled genomic DNA

Rare germline variants are difficult to identify using traditional sequencing due to relatively high cost and low throughput. Using second-generation sequencing, we report a targeted, cost-effective method to quantify rare SNPs from pooled genomic DNA. We pooled DNA from 1,111 individuals and target...

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Autors principals: Druley, Todd E, Vallania, Francesco LM, Wegner, Daniel J, Varley, Katherine E, Knowles, Olivia L, Bonds, Jacqueline A, Robison, Sarah W, Doniger, Scott W, Hamvas, Aaron, Cole, F. Sessions, Fay, Justin C, Mitra, Robi D
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776647/
https://ncbi.nlm.nih.gov/pubmed/19252504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1307
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