Mutations in the Human naked cuticle Homolog NKD1 Found in Colorectal Cancer Alter Wnt/Dvl/β-Catenin Signaling

BACKGROUND: Mutation of Wnt signal antagonists Apc or Axin activates β-catenin signaling in many cancers including the majority of human colorectal adenocarcinomas. The phenotype of apc or axin mutation in the fruit fly Drosophila melanogaster is strikingly similar to that caused by mutation in the...

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Bibliographic Details
Main Authors: Guo, Jianhui, Cagatay, Tolga, Zhou, Guangjin, Chan, Chih-Chiang, Blythe, Shelby, Suyama, Kaye, Zheng, Li, Pan, Kaifeng, Qian, Chiping, Hamelin, Richard, Thibodeau, Stephen N., Klein, Peter S., Wharton, Keith A., Liu, Wanguo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776356/
https://ncbi.nlm.nih.gov/pubmed/19956716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007982
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