Mutations in the Human naked cuticle Homolog NKD1 Found in Colorectal Cancer Alter Wnt/Dvl/β-Catenin Signaling

BACKGROUND: Mutation of Wnt signal antagonists Apc or Axin activates β-catenin signaling in many cancers including the majority of human colorectal adenocarcinomas. The phenotype of apc or axin mutation in the fruit fly Drosophila melanogaster is strikingly similar to that caused by mutation in the...

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Bibliographische Detailangaben
Hauptverfasser: Guo, Jianhui, Cagatay, Tolga, Zhou, Guangjin, Chan, Chih-Chiang, Blythe, Shelby, Suyama, Kaye, Zheng, Li, Pan, Kaifeng, Qian, Chiping, Hamelin, Richard, Thibodeau, Stephen N., Klein, Peter S., Wharton, Keith A., Liu, Wanguo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776356/
https://ncbi.nlm.nih.gov/pubmed/19956716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007982
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