Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects

BACKGROUND: FUS1/TUSC2 is a novel tumor suppressor located in the critical 3p21.3 chromosomal region frequently deleted in multiple cancers. We previously showed that Tusc2-deficient mice display a complex immuno-inflammatory phenotype with a predisposition to cancer. The goal of this study was to a...

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Detalhes bibliográficos
Main Authors: Ivanova, Alla V, Ivanov, Sergey V, Prudkin, Ljudmila, Nonaka, Daisuke, Liu, Zhandong, Tsao, Anne, Wistuba, Ignacio, Roth, Jack, Pass, Harvey I
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776015/
https://ncbi.nlm.nih.gov/pubmed/19852844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-91
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