Paired Box Gene 8-Peroxisome Proliferator-Activated Receptor-γ Fusion Protein and Loss of Phosphatase and Tensin Homolog Synergistically Cause Thyroid Hyperplasia in Transgenic Mice

Approximately 35% of follicular thyroid carcinomas and a small fraction of follicular adenomas are associated with a t(2;3)(q13;p25) chromosomal translocation that fuses paired box gene 8 (PAX8) with the peroxisome proliferator-activated receptor-γ gene (PPARG), resulting in expression of a PAX8-PPA...

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Autores principales: Diallo-Krou, Ericka, Yu, Jingcheng, Colby, Lesley A., Inoki, Ken, Wilkinson, John E., Thomas, Dafydd G., Giordano, Thomas J., Koenig, Ronald J.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Endocrine Society 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775974/
https://ncbi.nlm.nih.gov/pubmed/19797117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0701
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