Tipin/Tim1/And1 protein complex promotes Polα chromatin binding and sister chromatid cohesion

The Tipin/Tim1 complex plays an important role in the S-phase checkpoint and replication fork stability. However, the biochemical function of this complex is poorly understood. Using Xenopus laevis egg extract we show that Tipin is required for DNA replication in the presence of limiting amount of r...

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Autori principali: Errico, Alessia, Cosentino, Claudia, Rivera, Teresa, Losada, Ana, Schwob, Etienne, Hunt, Tim, Costanzo, Vincenzo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775894/
https://ncbi.nlm.nih.gov/pubmed/19893489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.304
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