Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success

BACKGROUND: Multiple short hairpin RNA (shRNA) gene therapy strategies are currently being investigated for treating viral diseases such as HIV-1. It is important to use several different shRNAs to prevent the emergence of treatment-resistant strains. However, there is evidence that repeated express...

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Autors principals: Mcintyre, Glen J, Yu, Yi-Hsin, Tran, Anna, Jaramillo, Angel B, Arndt, Allison J, Millington, Michelle L, Boyd, Maureen P, Elliott, Fiona A, Shen, Sylvie W, Murray, John M, Applegate, Tanya L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775741/
https://ncbi.nlm.nih.gov/pubmed/19878571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-6-184
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