Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death

CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR, 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) a compound with known antileukemic effect on B cell chronic lymphoblastic leukemia...

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Bibliografiska uppgifter
Huvudupphovsmän: Robert, Guillaume, Ben Sahra, Issam, Puissant, Alexandre, Colosetti, Pascal, Belhacene, Nathalie, Gounon, Pierre, Hofman, Paul, Bost, Fréderic, Cassuto, Jill-Patrice, Auberger, Patrick
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2009
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775681/
https://ncbi.nlm.nih.gov/pubmed/19924252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007889
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