Phase I Study of SU5416, a Small Molecule Inhibitor of the Vascular Endothelial Growth Factor Receptor (VEGFR) in Refractory Pediatric Central Nervous System Tumors

SU5416 is a novel small molecule tyrosine kinase inhibitor of the VEGF receptors 1 and 2. A phase I dose escalation study stratified by concurrent use (stratum II) or absence (Stratum I) of enzyme-inducing anticonvulsant drugs was undertaken to estimate the maximum-tolerated dose (MTD) and to descri...

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Main Authors: Kieran, Mark W., Supko, Jeffrey G., Wallace, Dana, Fruscio, Robert, Poussaint, Tina Young, Phillips, Peter, Pollack, Ian, Packer, Roger, Boyett, James M., Blaney, Susan, Prados, Michael, Geyer, Russ, Friedman, Henry, Goldman, Stewart, Kun, Larry E., MacDonald, Tobey
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775441/
https://ncbi.nlm.nih.gov/pubmed/19065567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.21873
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