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Effect of Potential Amine Prodrugs of Selective Neuronal Nitric Oxide Synthase Inhibitors on Blood-Brain Barrier Penetration

Several prodrug approaches were taken to mask amino groups in two potent and selective neuronal nitric oxide synthase (nNOS) inhibitors containing either a primary or secondary amino group to lower the charge and improve blood-brain barrier (BBB) penetration. The primary amine was masked as an azide...

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Hlavní autoři: Silverman, Richard B., Lawton, Graham R, Ranaivo, Hantamalala Ralay, Seo, Jiwon, Watterson, D. Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775413/
https://ncbi.nlm.nih.gov/pubmed/19796958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.08.065
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